GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs11723261 | 1 | rs79366248 | chr4:266659 | ZNF718 | chr4:53272-156488:+ | 0.34 | 4.66 | 4.33E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs793834 | 1 | rs793834 | chr6:24234933 | KAAG1 | chr6:24357131-24358512:+ | -0.25 | -4.19 | 3.51E-5 | Information processing speed |
| BLCA | cis | rs7112513 | 1 | rs7940310 | chr11:117024481 | PCSK7 | chr11:117075789-117102811:- | -0.4 | -5.02 | 7.91E-7 | Protein quantitative trait loci |
| BLCA | cis | rs6951245 | 1 | rs79422648 | chr7:1080241 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.41 | 1.33E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs2143950 | 1 | rs79436302 | chr14:35578797 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 4.26 | 2.6E-5 | Atopic dermatitis |
| BLCA | cis | rs6951245 | 1 | rs79443843 | chr7:1075245 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.36 | 1.69E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs9783347 | 1 | rs7947378 | chr11:18381327 | GTF2H1 | chr11:18343816-18388590:+ | 0.28 | 5.24 | 2.62E-7 | Pancreatic cancer |
| BLCA | cis | rs7927771 | 1 | rs7947730 | chr11:47786184 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.58 | 4.59E-8 | Subjective well-being |
| BLCA | cis | rs7112513 | 1 | rs7950364 | chr11:116898886 | PCSK7 | chr11:117075789-117102811:- | -0.4 | -5.15 | 4.22E-7 | Protein quantitative trait loci |
| BLCA | cis | rs7954638 | 1 | rs7954638 | chr12:96314795 | AMDHD1 | chr12:96337071-96362369:+ | 0.25 | 4.41 | 1.34E-5 | Metabolite levels (small molecules and protein measures) |
| BLCA | cis | rs9815354 | 1 | rs79548696 | chr3:41803385 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.73 | 3.79E-20 | Diastolic blood pressure |
| BLCA | cis | rs7956611 | 1 | rs7956611 | chr12:66904523 | CAND1 | chr12:67663061-67708388:+ | 0.21 | 3.93 | 0.000102 | Age of smoking initiation |
| BLCA | cis | rs6951245 | 1 | rs79617366 | chr7:1111958 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.47 | 1.05E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs6951245 | 1 | rs79683221 | chr7:1096139 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.41 | 1.33E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs2143950 | 1 | rs79702597 | chr14:35558856 | PPP2R3C | chr14:35554679-35591679:- | 0.28 | 4.46 | 1.08E-5 | Atopic dermatitis |